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  • Help me, about network sidesplit in network meta-analysis

    good evening to all,

    I am currently working on a network meta-analysis to assess the effects of A,B,C, and D drugs, utilizing the network command using STATA 17 SE. Specifically, I am attempting to investigate local inconsistency between A and B by running "network sidesplit A B." However, I encountered a problem as the following message appeared. Unfortunately, despite trying the "nosymmetric" option, I encountered the following persistent issue:
    "Warning: there is no evidence about the A-B contrast outside trials containing A and B
    mvmeta_bscov_proportional: mvmeta_mufrom sigma failed
    r(459);
    "
    Even when I attempted to run "network sidesplit all," only the AB portion seems to be missing in both direct and indirect as follow.
    Side Direct Indirect Difference
    Coef. Std. Err. Coef. Std. Err. Coef. Std. Err. P>z
    A B . . . . . . .
    A C .2333009 .1118497 .0447364 .1813231 .1885645 .220767 0.393
    A D .0834128 .1364211 .271976 .162957 -.1885632 .2207025 0.393
    C D .038676 .1183973 -.1498883 .1856149 .1885643 .2207366 0.393

    I have included the analysis data at the bottom of this post.
    As a beginner in this field, I am seeking guidance on how to resolve this issue. Your assistance in providing clear instructions would be greatly appreciated.
    study_number drug event total_number
    1 4 29 400
    1 1 16 400
    2 4 95 1989
    2 3 80 1773
    3 3 13 713
    3 1 12 730
    4 3 69 634
    4 4 66 596
    5 4 0 200
    5 1 2 200
    6 4 40 387
    6 1 26 380
    7 2 0 370
    7 1 8 372
    8 2 13 685
    8 1 15 678
    9 3 58 4623
    9 1 48 4617
    10 4 961 9235
    10 1 929 9186
    11 1 6 100
    11 4 8 100
    12 3 146 6741
    12 1 111 6716
    13 1 26 327
    13 4 26 334

  • #2
    I received following suggestion:

     The first line of the error message gives you the answer: there is no evidence about the A-B contrast outside trials containing A and B. That is, there is direct evidence but no indirect evidence. Now, the sidesplit command asks for the direct and indirect evidence to be compared. Clearly this is impossible and not interesting.

    I recommend that
    1. You use the nocodes option: -network setup event total_number, studyvar(study) trtvar(drug) rr ref(1) nocodes-. This keeps your existing copdes 1/2/3/4.
    2. You run -network map-. This shows that direct & indirect evidence are only between treatments 2/3/4.
    3. You run -network sidesplit all-. This picks out all the comparisons where there are both direct and indirect evidence.

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