Multivariate meta regression with unknown within-study covariance matrices

[Masoumeh Sanagou]

Dear STATALIST,

Is it possible to do Multivariate meta regression with unknown within-study covariance matrices in STATA?
Any advice about how I can estimate within-study covariance matrices?

Regards,

[Tiago Pereira]

Hi, Masoumeh.

How you will estimate the within-study var-covar matrices depends on the data available and type of outcome.

Check this paper:
https://pubmed.ncbi.nlm.nih.gov/23208849/

Once the variace-covariance structure is determined, a multivariate meta-regression model can be fitted via -meta mvregress-

[Jean-Michel Galarneau]

Just to add to this, there is a bit of a walkthrough by Bagos that I find very helpful and allows you to do it in gllamm.

https://pubmed.ncbi.nlm.nih.gov/26612788/